The current clinical management of Huntington's disease
Identifieur interne : 002589 ( Main/Exploration ); précédent : 002588; suivant : 002590The current clinical management of Huntington's disease
Auteurs : Wendy Phillips [Royaume-Uni] ; Kathleen M. Shannon [États-Unis] ; Roger A. Barker [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Clinical management, Cognition Disorders (drug therapy), Cognition Disorders (etiology), Diagnosis, Differential, Genetic Counseling, Humans, Huntington Disease (complications), Huntington Disease (therapy), Huntington disease, Huntington's disease, Mental Disorders (drug therapy), Mental Disorders (etiology), Movement Disorders (drug therapy), Movement Disorders (etiology), Nervous system diseases, Palliative Care, UHDRS, biomarkers, clinical features, juvenile Huntington's disease, management, multidisciplinary.
- MESH :
- complications : Huntington Disease.
- drug therapy : Cognition Disorders, Mental Disorders, Movement Disorders.
- etiology : Cognition Disorders, Mental Disorders, Movement Disorders.
- therapy : Huntington Disease.
- Diagnosis, Differential, Genetic Counseling, Humans, Palliative Care.
Abstract
Huntington's disease is a neurodegenerative condition, characterized by movement disorders, cognitive decline, and psychiatric disturbance. We review the pharmacological management of the various movement disorders associated with the disease, the cognitive decline and the commonly encountered behavioral disturbances. We discuss the nonclassical features of the disease, important in the management of these patients. Nonpharmacological support including genetic counseling and therapy and the importance of palliative care are also addressed. Finally, experimental approaches that may soon impact upon clinical practice are discussed. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21971
Affiliations:
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We review the pharmacological management of the various movement disorders associated with the disease, the cognitive decline and the commonly encountered behavioral disturbances. We discuss the nonclassical features of the disease, important in the management of these patients. Nonpharmacological support including genetic counseling and therapy and the importance of palliative care are also addressed. Finally, experimental approaches that may soon impact upon clinical practice are discussed. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Phillips, Wendy" sort="Phillips, Wendy" uniqKey="Phillips W" first="Wendy" last="Phillips">Wendy Phillips</name></noRegion><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. 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